Literature summary for 3.4.22.70 extracted from

Wang, J.; Zou, L.L.; Li, A.X.
Construction of a Streptococcus iniae sortase A mutant and evaluation of its potential as an attenuated modified live vaccine in Nile tilapia (Oreochromis niloticus) (2014), Fish Shellfish Immunol., 40, 392-398.

Search for more literature for 3.4.22.70

Application

Application	Comment	Organism
medicine	the mutant strain TBY-1DELTAsrtA is used as a live vaccine, which is administered via intraperitoneal injection. It provides the relative percent survival value of 95.5% in Nile tilapia, thereby demonstrating its high potential as an effective attenuated live vaccine candidate	Streptococcus iniae

Cloned(Commentary)

Cloned (Comment)	Organism
gene srtA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree	Streptococcus iniae

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of the mutant strain TBY-1DELTAsrtA via allelic exchange mutagenesis. The mutant strain has a lower survival capacity in healthy tilapia host blood and it is less virulent than the wild-type strain in tilapia	Streptococcus iniae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell wall	-	Streptococcus iniae	5618	-

Organism

Organism	UniProt	Comment	Textmining
Streptococcus iniae	M1L099	gene srtA	-
Streptococcus iniae TBY-1	M1L099	gene srtA	-

General Information

General Information	Comment	Organism
malfunction	the deletion of sortase A affects the virulence and infectious capacity of Streptococcus iniae	Streptococcus iniae

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Release 2023.1 (January 2023)