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Literature summary for 3.4.22.70 extracted from

  • Suree, N.; Yi, S.W.; Thieu, W.; Marohn, M.; Damoiseaux, R.; Chan, A.; Jung, M.E.; Clubb, R.T.
    Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors (2009), Bioorg. Med. Chem., 17, 7174-7185.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.70

Inhibitors

Inhibitors Comment Organism Structure
(4E)-5-methyl-4-[[(4-nitrophenyl)amino]methylidene]-2-phenyl-2,4-dihydro-3H-pyrazole-3-thione
-
 Staphylococcus aureus
(5Z)-3-(2,4-dimethylphenyl)-5-(3-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-3-(3-chlorophenyl)-5-(4-methyl-3-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-3-benzyl-5-benzylidene-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-3-ethyl-5-(2-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-methylphenyl)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(4-nitrophenyl)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-bromo-4-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-(3-chlorobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-benzylidene-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
(5Z)-5-benzylidene-3-propyl-2-thioxo-1,3-thiazolidin-4-one
-
 Staphylococcus aureus
2-(3,5-dichlorophenyl)-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3,5-dichlorophenyl)-5-ethoxy-4-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3-bromophenyl)-4,5-dichloropyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3-bromophenyl)-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3-bromophenyl)-4-chloro-5-ethoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3-bromophenyl)-5-chloro-4-ethoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3-bromophenyl)-5-chloro-4-methoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(3-chlorophenyl)-4-methoxy-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
2-(4-nitrophenyl)-4,5-dichloropyridazin-3-one
-
 Staphylococcus aureus
2-cyclohexyl-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
2-ethyl-4-hydroxy-5-(methylsulfanyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
2-phenyl-4,5-dichloro-pyridazin-3-one
-
 Staphylococcus aureus
4,5-dichloro-2-(3,5-dichlorophenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
4,5-dichloro-2-(3-fluorophenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
4,5-dichloro-2-(3-methylphenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
4,5-dichloro-2-cyclohexylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-(benzyloxy)-5-hydroxy-2-phenylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-(ethylsulfanyl)-2-(3-fluorophenyl)-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-(ethylsulfanyl)-2-(3-methylphenyl)-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-(ethylsulfanyl)-2-(4-nitrophenyl)-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-(ethylsulfanyl)-2-phenyl-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-(ethylsulfanyl)-5-hydroxy-2-phenylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-2-(3,5-dichlorophenyl)-5-ethoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-2-cyclohexyl-5-ethoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-5-(methylsulfanyl)-2-phenylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-5-ethoxy-2-(3-fluorophenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-5-ethoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-5-ethoxy-2-(4-nitrophenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
4-chloro-5-ethoxy-2-phenylpyridazin-3-one
-
 Staphylococcus aureus
4-ethoxy-2-phenyl-5-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
4-ethoxy-5-(2-pyridyldithio)-2-phenylpyridazin-3-one
-
 Staphylococcus aureus
4-ethoxy-5-(methyldithio)-2-phenylpyridazin-3-one
-
 Staphylococcus aureus
4-ethoxy-5-mercapto-2-phenylpyridazin-3-one
-
 Staphylococcus aureus
4-hydroxy-5-(methylsulfanyl)-2-phenylpyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-2-(3,5-dichlorophenyl)-4-ethoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-2-(3,5-dichlorophenyl)-4-methoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-2-(3-fluorophenyl)-4-methoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-2-cyclohexyl-4-ethoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-2-cyclohexyl-4-methoxypyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-4-ethoxy-2-(3-fluorophenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-4-ethoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-4-ethoxy-2-(4-nitrophenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-4-ethoxy-2-phenylpyridazin-3-one
-
 Staphylococcus aureus
5-chloro-4-methoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
-
 Staphylococcus aureus
5-chloro-4-methoxy-2-phenylpyridazin-3(2H)-one
-
 Staphylococcus aureus
5-ethoxy-2-(3-fluorophenyl)-4-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
5-ethoxy-2-(3-methylphenyl)-4-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
5-ethoxy-2-phenyl-4-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
5-hydroxy-4-methoxy-2-phenylpyridazin-3(2H)-one
-
 Staphylococcus aureus
5-methoxy-2-phenyl-4-sulfanylpyridazin-3(2H)-one
-
 Staphylococcus aureus
bis(4-ethoxy-2-phenyl-5-pyridazyl)disulfide
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-LPETG-Dap(Dnp)-NH2 + H2O
-
 Staphylococcus aureus ?
-
 ?

Synonyms

Synonyms Comment Organism
SrtA
-
 Staphylococcus aureus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00003
-
 4-ethoxy-5-(2-pyridyldithio)-2-phenylpyridazin-3-one in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus
0.0004
-
 4-ethoxy-5-(methyldithio)-2-phenylpyridazin-3-one in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-ethoxy-2-phenyl-5-sulfanylpyridazin-3(2H)-one
0.001
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-5-ethoxy-2-phenylpyridazin-3-one
0.0014
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-(ethylsulfanyl)-2-phenyl-5-sulfanylpyridazin-3(2H)-one
0.0015
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus bis(4-ethoxy-2-phenyl-5-pyridazyl)disulfide
0.0031
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-ethoxy-2-(3-methylphenyl)-4-sulfanylpyridazin-3(2H)-one
0.0033
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-(ethylsulfanyl)-2-(3-methylphenyl)-5-sulfanylpyridazin-3(2H)-one
0.0037
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one
0.0044
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-ethoxy-2-phenyl-4-sulfanylpyridazin-3(2H)-one
0.0045
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3-chlorophenyl)-4-methoxy-5-sulfanylpyridazin-3(2H)-one
0.0052
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (4E)-5-methyl-4-[[(4-nitrophenyl)amino]methylidene]-2-phenyl-2,4-dihydro-3H-pyrazole-3-thione
0.0055
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-(ethylsulfanyl)-2-(3-fluorophenyl)-5-sulfanylpyridazin-3(2H)-one
0.0057
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-ethoxy-2-(3-fluorophenyl)-4-sulfanylpyridazin-3(2H)-one
0.0093
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-methoxy-2-phenyl-4-sulfanylpyridazin-3(2H)-one
0.012
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(4-nitrophenyl)-2-thioxo-1,3-thiazolidin-4-one
0.013
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-ethoxy-5-mercapto-2-phenylpyridazin-3-one
0.014
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one
0.015
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-methylphenyl)-2-thioxo-1,3-thiazolidin-4-one
0.017
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one
0.0179
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-cyclohexyl-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
0.03
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-(ethylsulfanyl)-2-(4-nitrophenyl)-5-sulfanylpyridazin-3(2H)-one
0.035
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-bromo-4-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one
0.05
-
 IC50 above 0.05 mM, Staphylococcus aureus 4-(ethylsulfanyl)-5-hydroxy-2-phenylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, Staphylococcus aureus 4-(benzyloxy)-5-hydroxy-2-phenylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, Staphylococcus aureus 5-hydroxy-4-methoxy-2-phenylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-5-ethoxy-2-(3-fluorophenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-5-ethoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-2-(3,5-dichlorophenyl)-5-ethoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-2-cyclohexyl-5-ethoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3-bromophenyl)-4,5-dichloropyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-2-(3,5-dichlorophenyl)-4-methoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-2-(3-fluorophenyl)-4-methoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-4-methoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-4-methoxy-2-phenylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-2-cyclohexyl-4-methoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-4-ethoxy-2-(3-fluorophenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-4-ethoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3-bromophenyl)-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-5-(methylsulfanyl)-2-phenylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-4-ethoxy-2-(4-nitrophenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-2-cyclohexyl-4-ethoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-hydroxy-5-(methylsulfanyl)-2-phenylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4,5-dichloro-2-(3-fluorophenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-2-(3,5-dichlorophenyl)-4-ethoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4,5-dichloro-2-cyclohexylpyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4,5-dichloro-2-(3-methylphenyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-ethyl-4-hydroxy-5-(methylsulfanyl)pyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3-bromophenyl)-4-chloro-5-ethoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3-bromophenyl)-5-chloro-4-ethoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3-bromophenyl)-5-chloro-4-methoxypyridazin-3(2H)-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 5-chloro-4-ethoxy-2-phenylpyridazin-3-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-phenyl-4,5-dichloro-pyridazin-3-one
0.05
-
 IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(4-nitrophenyl)-4,5-dichloropyridazin-3-one
0.061
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4,5-dichloro-2-(3,5-dichlorophenyl)pyridazin-3(2H)-one
0.104
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-3-ethyl-5-(2-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
0.109
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-(3-chlorobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
0.119
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-3-(2,4-dimethylphenyl)-5-(3-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
0.166
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3,5-dichlorophenyl)-5-ethoxy-4-sulfanylpyridazin-3(2H)-one
0.186
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-benzylidene-3-propyl-2-thioxo-1,3-thiazolidin-4-one
0.199
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-benzylidene-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
0.219
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 4-chloro-5-ethoxy-2-(4-nitrophenyl)pyridazin-3(2H)-one
0.301
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus 2-(3,5-dichlorophenyl)-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
0.405
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
0.492
-
 in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-3-benzyl-5-benzylidene-2-thioxo-1,3-thiazolidin-4-one
1
-
 IC50 above 1.0 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C Staphylococcus aureus (5Z)-3-(3-chlorophenyl)-5-(4-methyl-3-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one