Literature summary for 3.4.22.70 extracted from

Kruger, R.G.; Barkallah, S.; Frankel, B.A.; McCafferty, D.G.
Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics (2004), Bioorg. Med. Chem., 12, 3723-3729.

Search for more literature for 3.4.22.70

Inhibitors

Inhibitors	Comment	Organism	Structure
NH2-YALPE-AlaPsi(PO2H-CH2)Gly-EE-NH2	nonhydrolyzable phosphinic peptidomimetic inhibitor of SrtA derived from the LPXTG substrate sequence, simple reversible competitive inhibitor	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Abz-LPETG-Dap(Dnp) + GGGGG	-	Staphylococcus aureus	Abz-LPETGGGGG + G-Dap(Dnp)	-	?
Abz-LPETG-Dap(Dnp) + H2O	-	Staphylococcus aureus	Abz-LPET + G-Dap(Dnp)	-	?

Synonyms

Synonyms	Comment	Organism
sortase transpeptidase	-	Staphylococcus aureus
SrtA	-	Staphylococcus aureus

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Release 2023.1 (January 2023)