Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3,3-trifluoro-1-(phenylsulfonyl)-1-propene | IC50: 0.19 mM, irreversible | Staphylococcus aureus | |
cis-1,2-bis(phenylsulfonyl)ethylene | IC50: 0.00113 mM, irreversible | Staphylococcus aureus | |
divinyl sulfone | IC50: 0.00106 mM, irreversible | Staphylococcus aureus | |
ethyl vinyl sulfone | IC50: 0.00471 mM, irreversible | Staphylococcus aureus | |
methyl vinyl sulfone | IC50: 0.00624 mM, irreversible | Staphylococcus aureus | |
additional information | no inhibition by phenyl trans-styryl sulfone | Staphylococcus aureus | |
phenyl vinyl sulfone | IC50: 0.736 mM, irreversible | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Staphylococcus aureus | the transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus | Staphylococcus aureus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SrtA | - |
Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00106 | - |
IC50: 0.00106 mM, irreversible | Staphylococcus aureus | divinyl sulfone | |
0.00113 | - |
IC50: 0.00113 mM, irreversible | Staphylococcus aureus | cis-1,2-bis(phenylsulfonyl)ethylene | |
0.00471 | - |
IC50: 0.00471 mM, irreversible | Staphylococcus aureus | ethyl vinyl sulfone | |
0.00624 | - |
IC50: 0.00624 mM, irreversible | Staphylococcus aureus | methyl vinyl sulfone | |
0.19 | - |
IC50: 0.19 mM, irreversible | Staphylococcus aureus | 3,3,3-trifluoro-1-(phenylsulfonyl)-1-propene | |
0.736 | - |
IC50: 0.736 mM, irreversible | Staphylococcus aureus | phenyl vinyl sulfone |