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Literature summary for 3.4.22.70 extracted from

  • Frankel, B.A.; Bentley, M.; Kruger, R.G.; McCafferty, D.G.
    Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus (2004), J. Am. Chem. Soc., 126, 3404-3405.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,3,3-trifluoro-1-(phenylsulfonyl)-1-propene IC50: 0.19 mM, irreversible Staphylococcus aureus
cis-1,2-bis(phenylsulfonyl)ethylene IC50: 0.00113 mM, irreversible Staphylococcus aureus
divinyl sulfone IC50: 0.00106 mM, irreversible Staphylococcus aureus
ethyl vinyl sulfone IC50: 0.00471 mM, irreversible Staphylococcus aureus
methyl vinyl sulfone IC50: 0.00624 mM, irreversible Staphylococcus aureus
additional information no inhibition by phenyl trans-styryl sulfone Staphylococcus aureus
phenyl vinyl sulfone IC50: 0.736 mM, irreversible Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus aureus the transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus ?
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus Staphylococcus aureus ?
-
?

Synonyms

Synonyms Comment Organism
SrtA
-
Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00106
-
IC50: 0.00106 mM, irreversible Staphylococcus aureus divinyl sulfone
0.00113
-
IC50: 0.00113 mM, irreversible Staphylococcus aureus cis-1,2-bis(phenylsulfonyl)ethylene
0.00471
-
IC50: 0.00471 mM, irreversible Staphylococcus aureus ethyl vinyl sulfone
0.00624
-
IC50: 0.00624 mM, irreversible Staphylococcus aureus methyl vinyl sulfone
0.19
-
IC50: 0.19 mM, irreversible Staphylococcus aureus 3,3,3-trifluoro-1-(phenylsulfonyl)-1-propene
0.736
-
IC50: 0.736 mM, irreversible Staphylococcus aureus phenyl vinyl sulfone