Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(benzylsulfanyl)-4-(3-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(benzylsulfanyl)-4-(4-methoxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(benzylsulfanyl)-4-(4-methylphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
2-(benzylsulfanyl)-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
2-[(4-nitrobenzyl)sulfanyl]-4-(3-nitrophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
2-[(4-nitrobenzyl)sulfanyl]-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(3-nitrophenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(4-chlorophenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(4-chlorophenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(4-methoxyphenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(4-methoxyphenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(4-methylphenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
4-(4-methylphenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus | |
6-oxo-4-phenyl-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln + Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SARS-CoV 3CL protease | - |
Severe acute respiratory syndrome-related coronavirus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 4-(3-nitrophenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 4-(4-methylphenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 6-oxo-4-phenyl-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 2-(benzylsulfanyl)-4-(4-methylphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 2-(benzylsulfanyl)-4-(3-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 2-(benzylsulfanyl)-4-(4-methoxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 2-(benzylsulfanyl)-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile | |
additional information | - |
IC50 above 0.05 mM | Severe acute respiratory syndrome-related coronavirus | 4-(4-methylphenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | |
0.0061 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4-(4-chlorophenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
0.0106 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-[(4-nitrobenzyl)sulfanyl]-4-(3-nitrophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
0.0169 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4-(4-chlorophenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | |
0.0203 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4-(4-methoxyphenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile | |
0.0263 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 4-(4-methoxyphenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | |
0.0353 | - |
- |
Severe acute respiratory syndrome-related coronavirus | 2-[(4-nitrobenzyl)sulfanyl]-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile |