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Literature summary for 3.4.22.69 extracted from

  • Kuo, C.J.; Liu, H.G.; Lo, Y.K.; Seong, C.M.; Lee, K.I.; Jung, Y.S.; Liang, P.H.
    Individual and common inhibitors of coronavirus and picornavirus main proteases (2009), FEBS Lett., 583, 549-555.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-butyl-N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1H-benzimidazol-2-amine
-
Severe acute respiratory syndrome-related coronavirus
2-acetyl-3-(3-iodophenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazole
-
Severe acute respiratory syndrome-related coronavirus
2-benzyl-2H-isoindole-4,7-dione
-
Severe acute respiratory syndrome-related coronavirus
3-(4-bromophenyl)-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-(1H-imidazol-1-yl)-4,5-dihydro-1H-pyrazole
-
Severe acute respiratory syndrome-related coronavirus
4-methoxy-6-[([1,3]thiazolo[5,4-b]pyridin-2-ylsulfinyl)methyl]-2H-pyran-2-one
-
Severe acute respiratory syndrome-related coronavirus
4-[(E)-[(2-methoxyphenyl)imino]methyl]-2-phenyl-1,3-oxazol-5-yl acetate
-
Severe acute respiratory syndrome-related coronavirus
5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one
-
Severe acute respiratory syndrome-related coronavirus
N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1-ethyl-1H-benzimidazol-2-amine
-
Severe acute respiratory syndrome-related coronavirus
N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1-propyl-1H-benzimidazol-2-amine
-
Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O
-
Severe acute respiratory syndrome-related coronavirus Dabcyl-KTSAVLQ + SGFRKME-EDANS
-
?

Synonyms

Synonyms Comment Organism
SARS-CoV 3CLpro
-
Severe acute respiratory syndrome-related coronavirus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
-
Severe acute respiratory syndrome-related coronavirus 3-(4-bromophenyl)-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-(1H-imidazol-1-yl)-4,5-dihydro-1H-pyrazole
0.0033
-
-
Severe acute respiratory syndrome-related coronavirus 4-[(E)-[(2-methoxyphenyl)imino]methyl]-2-phenyl-1,3-oxazol-5-yl acetate
0.007
-
-
Severe acute respiratory syndrome-related coronavirus 2-benzyl-2H-isoindole-4,7-dione
0.0072
-
-
Severe acute respiratory syndrome-related coronavirus 4-methoxy-6-[([1,3]thiazolo[5,4-b]pyridin-2-ylsulfinyl)methyl]-2H-pyran-2-one
0.008
-
-
Severe acute respiratory syndrome-related coronavirus N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1-propyl-1H-benzimidazol-2-amine
0.0081
-
-
Severe acute respiratory syndrome-related coronavirus 1-butyl-N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1H-benzimidazol-2-amine
0.0084
-
-
Severe acute respiratory syndrome-related coronavirus N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1-ethyl-1H-benzimidazol-2-amine
0.0098
-
-
Severe acute respiratory syndrome-related coronavirus 2-acetyl-3-(3-iodophenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazole
0.0106
-
-
Severe acute respiratory syndrome-related coronavirus 5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one