Literature summary for 3.4.22.69 extracted from

Chen, S.; Hu, T.; Zhang, J.; Chen, J.; Chen, K.; Ding, J.; Jiang, H.; Shen, X.
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease. Crystal structure with molecular dynamics simulations (2008), J. Biol. Chem., 283, 554-564.

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Cloned(Commentary)

Cloned (Comment)	Organism
mutant enzyme G11A and wild-type enzyme are expressed in Escherichia coli	Alphacoronavirus

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of monomeric mutant enzyme G11A	Alphacoronavirus

Protein Variants

Protein Variants	Comment	Organism
G11A	mutation entirely abolishes activity	Alphacoronavirus

Organism

Organism	UniProt	Comment	Textmining
Alphacoronavirus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Alphacoronavirus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[4-(4-dimethylaminophenylazo)benzoic acid]-VNSTLQSGLRK-[5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid]-M + H2O	-	Alphacoronavirus	?	-	?

Synonyms

Synonyms	Comment	Organism
3cLpro	-	Alphacoronavirus
coronavirus 3C-like protease	-	Alphacoronavirus
SARS-CoV 3C-like protease	-	Alphacoronavirus

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Release 2023.1 (January 2023)