KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | steady-state analysis of the solvent isotope effects on KM-value | Severe acute respiratory syndrome-related coronavirus | |
0.045 | - |
[4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQSGFRKME-5-['-(aminoethyl)amino]-naphthalenesulfonic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
0.073 | - |
SITSAVLQ-p-nitrophenyl ester | - |
Severe acute respiratory syndrome-related coronavirus | |
0.18 | - |
SITSAVLQ-p-nitroanilide | - |
Severe acute respiratory syndrome-related coronavirus | |
0.6 | - |
SITSAVLQSGFRKMA | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a 3CLpro mechanism utilizes an electrostatic trigger to initiate the acylation reaction, a cysteine-histidine catalytic dyad ion pair, an enzyme-facilitated release of P1, and a general base catalyzed deacylation reaction | Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
SITSAVLQ-p-nitroanilide + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
SITSAVLQ-p-nitrophenyl ester + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
SITSAVLQSGFRKMA + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
[4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQSGFRKME-5-['-(aminoethyl)amino]-naphthalenesulfonic acid + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
[4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQSGFRKME-5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid + H2O | - |
Severe acute respiratory syndrome-related coronavirus | [4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQ + SGFRKME-5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid | - |
? | |
[4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQSGFRKME-[5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid] + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | steady-state analysis of the solvent isotope effects on kcat | Severe acute respiratory syndrome-related coronavirus | |
0.6 | - |
SITSAVLQ-p-nitrophenyl ester | - |
Severe acute respiratory syndrome-related coronavirus | |
0.86 | - |
SITSAVLQ-p-nitroanilide | - |
Severe acute respiratory syndrome-related coronavirus | |
1.5 | - |
[4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQSGFRKME-5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid | - |
Severe acute respiratory syndrome-related coronavirus | |
8.5 | - |
SITSAVLQSGFRKMA | - |
Severe acute respiratory syndrome-related coronavirus |