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Literature summary for 3.4.22.68 extracted from

  • Mukhopadhyay, D.; Arnaoutov, A.; Dasso, M.
    The SUMO protease SENP6 is essential for inner kinetochore assembly (2010), J. Cell Biol., 188, 681-692.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
small ubiquitin-related modifier-CENP-I + H2O Homo sapiens SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins small ubiquitin-related modifier-protein + CENP-I
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 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
small ubiquitin-related modifier-CENP-I + H2O SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins Homo sapiens small ubiquitin-related modifier-protein + CENP-I
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 r

Synonyms

Synonyms Comment Organism
SENP6
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 Homo sapiens
small ubiquitin-like modifier protease
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 Homo sapiens
SUMO protease
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 Homo sapiens

General Information

General Information Comment Organism
malfunction cells lacking SENP6 show defects in spindle assembly and metaphase chromosome congression. A subset of proteins become undetectable on inner kinetochores after SENP6 depletion, particularly the CENP-H/I/K complex, whereas other changes in kinetochore composition mimick defects previously reported to result from CENP-H/I/K depletion, SENP6 depletion results in loss of the CENP-H/I/K complex from kinetochores, detailed overview Homo sapiens
physiological function the SUMO protease SENP6 is essential for inner kinetochore assembly. SENP6 stabilizes CENP-I by antagonizing RNF4, RNF4, a ubiquitin ligase which targets polysumoylated proteins for proteasomal degradation. CENP-I is degraded through the action of RNF4 Homo sapiens