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Literature summary for 3.4.22.68 extracted from
- A new protease required for cell-cycle progression in yeast (1999), Nature, 398, 246-251.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | there may be a connection between a defect in SUMO-1 conjugation to the PML protein and acute promyelocytic leukemia (ALP). Specific Ulp inhibitors can therefore have therapeutic value for ALP | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | there may be a connection between a defect in SUMO-1 conjugation to the PML protein and acute promyelocytic leukemia (ALP). Specific Ulp inhibitors can therefore have therapeutic value for ALP | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SUMO-1 protein + H2O | Saccharomyces cerevisiae | the enzyme plays an essential role in the G2/M phase of the cell cycle | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | Q02724 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| His6-Smt3-hemagglutinin fusion protein + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| His6-Smt3-Leu-beta-galactosidase + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| His6-Smt3-Met-beta-galactosidase + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| SUMO-1 protein + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| SUMO-1 protein + H2O | the enzyme plays an essential role in the G2/M phase of the cell cycle | Saccharomyces cerevisiae | ? | - |
? | |
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