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Literature summary for 3.4.22.66 extracted from

  • Kuyumcu-Martinez, M.; Belliot, G.; Sosnovtsev, S.V.; Chang, K.O.; Green, K.Y.; Lloyd, R.E.
    Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein (2004), J. Virol., 78, 8172-8182.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.66

Application

Application Comment Organism
medicine calicivirus 3CLpro mediates the cleavage of poly(A)-binding protein as part of its strategy to inhibit cellular translation norovirus
medicine poliovirus 3Cpro mediates the cleavage of poly(A)-binding protein as part of its strategy to inhibit cellular translation Enterovirus C

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) feline calicivirus
expression in HeLa cells norovirus

Organism

Organism UniProt Comment Textmining
Enterovirus C
-
-
-
feline calicivirus Q66914
-
-
norovirus
-
-
-
norovirus MD145-12
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(A)-binding protein cleavage separates the C-terminal domain of the substrate that binds translation factors eIF4B and eRF3 from the N-terminal RNA-binding domain Enterovirus C ?
-
 ?
poly(A)-binding protein cleavage separates the C-terminal domain of the substrate that binds translation factors eIF4B and eRF3 from the N-terminal RNA-binding domain norovirus ?
-
 ?
poly(A)-binding protein cleavage separates the C-terminal domain of the substrate that binds translation factors eIF4B and eRF3 from the N-terminal RNA-binding domain norovirus MD145-12 ?
-
 ?
Poly(A)-binding protein + H2O cleavage separates the C-terminal domain of the substrate that binds translation factors eIF4B and eRF3 from the N-terminal RNA-binding domain feline calicivirus ?
-
 ?

Synonyms

Synonyms Comment Organism
3C-like proteinase
-
 norovirus
3C-like proteinase
-
 feline calicivirus
FCV 3CLpro
-
 feline calicivirus
NoV 3CLpro
-
 norovirus
PV 3Cpro
-
 Enterovirus C