Literature summary for 3.4.22.65 extracted from

Adam, E.; Hansen, K.K.; Astudillo, O.F.; Coulon, L.; Bex, F.; Duhant, X.; Jaumotte, E.; Hollenberg, M.D.; Jacquet, A.
The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism (2006), J. Biol. Chem., 281, 6910-6923.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Der p 1 stimulates the expression of Interleukin-8 in human pulmonary epithelial cells via the ERK1/2 signaling pathway	Dermatophagoides pteronyssinus

Application

Application	Comment	Organism
medicine	induces biological responses in a human airway-derived epithelial cell line	Dermatophagoides pteronyssinus

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant ProDer p 1 from CHO cells	Dermatophagoides pteronyssinus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Dermatophagoides pteronyssinus	the house dust mite allergen Der p 1 stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Dermatophagoides pteronyssinus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
immunoaffinity chromatography using immobilized 4C1 anti-Der p 1 monoclonal antibody	Dermatophagoides pteronyssinus

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the house dust mite allergen Der p 1 stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism	Dermatophagoides pteronyssinus	?	-	?
N-tert-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O	-	Dermatophagoides pteronyssinus	N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
allergen Der p	-	Dermatophagoides pteronyssinus
Der p 1	-	Dermatophagoides pteronyssinus
house dust mite allergen	-	Dermatophagoides pteronyssinus

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Release 2023.1 (January 2023)