Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.65 extracted from

  • John, R.J.; Rusznak, C.; Ramjee, M.; Lamont, A.G.; Abrahamson, M.; Hewitt, E.L.
    Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor (2000), Clin. Exp. Allergy, 30, 784-793.
    View publication on PubMed
Search for more literature for 3.4.22.65

Inhibitors

Inhibitors Comment Organism Structure
cystatin A
-
 Dermatophagoides pteronyssinus
cystatin C
-
 Dermatophagoides pteronyssinus
cystatin D
-
 Dermatophagoides pteronyssinus
cystatin E/M
-
 Dermatophagoides pteronyssinus
E-64
-
 Dermatophagoides pteronyssinus
PTL11028 a highly potent and specific inhibitor, being effective against both purified protease and Der p 1 within HDM extract Dermatophagoides pteronyssinus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 2-aminobenzoic acid-Val-Ala-Nle-Ser-(3-nitro)-tyrosinyl-aspartamide pH 8.3 Dermatophagoides pteronyssinus

Organism

Organism UniProt Comment Textmining
Dermatophagoides pteronyssinus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoic acid-Val-Ala-Nle-Ser-(3-nitro)-tyrosinyl-aspartamide + H2O
-
 Dermatophagoides pteronyssinus ?
-
 ?
CD23 + H2O
-
 Dermatophagoides pteronyssinus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.2
-
 2-aminobenzoic acid-Val-Ala-Nle-Ser-(3-nitro)-tyrosinyl-aspartamide pH 8.3 Dermatophagoides pteronyssinus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000005
-
 cystatin A pH 8.3 Dermatophagoides pteronyssinus
0.0000148
-
 cystatin E/M pH 8.3 Dermatophagoides pteronyssinus
0.0000279
-
 cystatin C pH 8.3 Dermatophagoides pteronyssinus
0.00126
-
 cystatin D pH 8.3 Dermatophagoides pteronyssinus