Literature summary for 3.4.22.64 extracted from

Huang, W.; Xie, W.B.; Qiao, D.; Qiu, P.; Huang, E.; Li, B.; Chen, C.; Liu, C.; Wang, Q.; Lin, Z.; Wang, H.
Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis (2015), Toxicol. Sci., 145, 68-79.

Search for more literature for 3.4.22.64

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme downregulation by siRNA	Homo sapiens
additional information	enzyme downregulation by siRNA and shRNA sequence targeting caspase-11	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
wedelolactone	a specific inhibitor of caspase-11	Homo sapiens
wedelolactone	a specific inhibitor of caspase-11	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-
Rattus norvegicus Sprague Dawley	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the enzyme requires activation through proteolytic cleavage	Homo sapiens
proteolytic modification	the enzyme requires activation through proteolytic cleavage	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
midbrain	-	Rattus norvegicus	-
neuron	dopaminergic	Homo sapiens	-
neuron	dopaminergic	Rattus norvegicus	-
PC-12 cell	-	Rattus norvegicus	-
SH-SY5Y cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
malfunction	inhibition of caspase-11 expression with either wedelolactone or siRNAs reduces the number of methamphetamine-induced apoptotic cells, silencing of caspase-11 protects PC-12 cells from methamphetamine-induced apoptosis. In addition, blocking caspase-11 expression inhibits methamphetamine-induced activation of caspase-3 and PARP in vitro and in vivo	Rattus norvegicus
malfunction	inhibition of caspase-11 expression with either wedelolactone or siRNAs reduces the number of methamphetamine-induced apoptotic cells. In addition, blocking caspase-11 expression inhibits methamphetamine-induced activation of caspase-3 and PARP in vitro and in vivo	Homo sapiens
physiological function	caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis, the caspase-11/caspase-3 signal pathway is involved in methamphetamine-induced neurotoxicity	Homo sapiens
physiological function	caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis, the caspase-11/caspase-3 signal pathway is involved in methamphetamine-induced neurotoxicity	Rattus norvegicus

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Release 2023.1 (January 2023)