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Literature summary for 3.4.22.64 extracted from
- PARP-1 regulates the expression of caspase-11 (2011), Biochem. Biophys. Res. Commun., 408, 489-493.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | poly(ADP-ribose) polymerase-1, PARP-1, regulates the expression of caspase-11 following lipopolysaccharide stimulation. PARP-1 is recruited to the caspase-11 promoter region containing predicted nuclear factor (NF)-kappaB-binding sites, but PARP-1 enzymatic activity is not required for the caspase-11 upregulation. PARP-1 can regulate the induction of caspase-11 at a transcriptional level. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB | additional information |
| Homo sapiens | induction of caspase-11 is dependent on NF-kappaB. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB. Lipopolysaccharide induce the enzyme expression | up |
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