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Literature summary for 3.4.22.64 extracted from

  • Kang, S.J.; Wang, S.; Hara, H.; Peterson, E.P.; et al.
    Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions (2000), J. Cell Biol., 149, 613-622.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS ?
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?
procaspase-1 + H2O Mus musculus
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?
-
?
procaspase-3 + H2O Mus musculus the enzyme is a critical initiator caspase responsible for the activation of caspase-3 ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-11 can autoprocess itself in vitro Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain caspase-11 is upregulated in a subpopulation of cells i brain after ischemic injury Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information optimal cleavage site is IEHD, LEHD, VEHD or PEHD Mus musculus ?
-
?
additional information the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS Mus musculus ?
-
?
procaspase-1 + H2O
-
Mus musculus ?
-
?
procaspase-1 + H2O the enzyme is an upstream activator of caspase-1 Mus musculus ?
-
?
procaspase-3 + H2O
-
Mus musculus ?
-
?
procaspase-3 + H2O the enzyme is a critical initiator caspase responsible for the activation of caspase-3 Mus musculus ?
-
?