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Literature summary for 3.4.22.63 extracted from

  • Raulf, N.; El-Attar, R.; Kulms, D.; Lecis, D.; Delia, D.; Walczak, H.; Papenfuss, K.; Odell, E.; Tavassoli, M.
    Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10 (2014), Br. J. Cancer, 111, 1955-1964.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information in head and neck squamous cancer cell lines with low caspase-8 levels, Smac mimetics treatment induced caspase-10 activation Homo sapiens

Application

Application Comment Organism
pharmacology tumour necrosis factor-related apoptosis-inducing ligand and SMs effectively kill head and neck squamous cancer cell lines and therefore represent potential targeted therapeutics for head and neck cancer. Distinct molecular mechanisms determine the sensitivity to each agent, with levels of TNF-alpha, caspase-8, Bid and caspase-10 providing important predictive biomarkers of response to these agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CBZ-VAD-trifluoromethylketone pancaspase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
head and neck squamous cancer cell nine different cell lines, caspase-10 fragments are specifically detected in Smac mimetic-sensitive HSC3 cells Homo sapiens
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General Information

General Information Comment Organism
physiological function Smac mimetic-induced cell death is associated with caspase-10 activation and is Bid-independent, suggesting that in the absence of caspase-8, caspase-10 mediates response to Smac mimetics, overview Homo sapiens