Literature summary for 3.4.22.63 extracted from

Wang, H.; Wang, P.; Sun, X.; Luo, Y.; Wang, X.; Ma, D.; Wu, J.
Cloning and characterization of a novel caspase-10 isoform that activates NF-kB activity (2007), Biochim. Biophys. Acta, 1770, 1528-1537.

Search for more literature for 3.4.22.63

Cloned(Commentary)

Cloned (Comment)	Organism
splice variant caspase-10g (comprising five exons including exons 2-5 and a specific exon between exons 5 and 6 of the caspase-10 gene), expression in HeLa and JURKAT cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the splice variant caspase-10g (comprising five exons including exons 2-5 and a specific exon between exons 5 and 6 of the caspase-10 gene), a prodomain-only isoform of caspase-10, may play a regulatory role preferentially in the NF-kappaB pathway. Caspase-10g induces low level of apoptosis and has no effect on the caspase-10a-mediated cell apoptosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92851	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the splice variant caspase-10g (comprising five exons including exons 2-5 and a specific exon between exons 5 and 6 of the caspase-10 gene), a prodomain-only isoform of caspase-10, may play a regulatory role preferentially in the NF-kappaB pathway. Caspase-10g induces low level of apoptosis and has no effect on the caspase-10a-mediated cell apoptosis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
caspase-10	-	Homo sapiens
FLICE2	-	Homo sapiens
Mch4	-	Homo sapiens

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Release 2023.1 (January 2023)