Cloned (Comment) | Organism |
---|---|
expression of both the long and short isoforms of the wild-type or the caspase-10 mutants are transfected into Hela or MCF-7 cells together with a bet-gal reporter construct | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.071 | - |
DEVD-7-amido-4-methylcoumarin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92851 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | autoprocessing, the wild-type 55000 Da GST fusion protein is cleaved to the 43000 Da active form | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DEVD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | DEVD + 7-amino-4-methylcoumarin | - |
? | |
additional information | inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells | Homo sapiens | ? | - |
? | |
YVAD-7-amido-4-methylcoumarin + H2O | less efficient cleavage than DEVD-7-amido-4-methylcoumarin | Homo sapiens | YVAD + 7-amino-4-methylcoumarin | - |
? |