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Literature summary for 3.4.22.62 extracted from

  • Lu, E.P.; McLellan, M.; Ding, L.; Fulton, R.; Mardis, E.R.; Wilson, R.K.; Miller, C.A.; Westervelt, P.; DiPersio, J.F.; Link, D.C.; Walter, M.J.; Ley, T.J.; Graubert, T.A.
    Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice (2014), Blood, 124, 3887-3895.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57/BL6J
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cell
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Mus musculus
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erythroid cell
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Mus musculus
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lymphoid cell
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Mus musculus
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myeloid cell
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Mus musculus
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Synonyms

Synonyms Comment Organism
casp9
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Mus musculus

General Information

General Information Comment Organism
malfunction loss of caspase-9 results in increased DNA damage and mutation burden after exposure to alkylating agents. Casp9 deficiency results in decreased erythroid and B-cell progenitor abundance and impaired function of hematopoietic stem cells after transplantation. Loss of Casp9 alters hematopoietic progenitor cell frequency Mus musculus
physiological function caspase-9 is required for normal development of myeloid, lymphoid, and erythroid cells in mice. Role of caspase-9, the initiator caspase of the intrinsic apoptotic cascade, in murine fetal and adult hematopoiesis, overview Mus musculus