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Literature summary for 3.4.22.62 extracted from

  • Jen, C.Y.; Lin, C.Y.; Leu, S.F.; Huang, B.M.
    Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis through caspase-9 pathway (2009), Evid. Based. Complement Alternat. Med., 2009, 1-10.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.62

Activating Compound

Activating Compound Comment Organism Structure
cordycepin i.e. 3'-deoxyadenosine, cells treated with 100 mM and 1 mM for 24 h, expression of caspase-9, Western blot analysis Mus musculus

Application

Application Comment Organism
pharmacology studies on the mechanism of cordycepin-induced apoptosis in MA-10 Leydig tumor cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone i.e. Z-VAD-FMK, treatment with 100 microM caspase inhibitor in combination with 100 microM cordycepin for 24 h suppresses sub-G1 phase in MA-10 cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Mus musculus mechanisms of cordycepin-induced apoptosis, activation of caspase-9, caspase-3 and caspase-7 caspase-3 + ?
-
 ?
pro-caspase-7 + H2O Mus musculus mechanisms of cordycepin-induced apoptosis, activation of caspase-9, caspase-3 and caspase-7 caspase-7 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9R0T0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell
-
 Mus musculus
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MA-10 cell
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 Western blot analysis reveals cordycepin-induced expression of caspase-9, activation of caspase-3 and caspase-7, but not of caspase-8 in a time- and dose-dependent manner, cordycepin-induced apoptosis acts through a caspase-9 and caspase-3 and caspase-7 dependent pathway Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-caspase-3 + H2O mechanisms of cordycepin-induced apoptosis, activation of caspase-9, caspase-3 and caspase-7 Mus musculus caspase-3 + ?
-
 ?
pro-caspase-7 + H2O mechanisms of cordycepin-induced apoptosis, activation of caspase-9, caspase-3 and caspase-7 Mus musculus caspase-7 + ?
-
 ?