Literature summary for 3.4.22.62 extracted from

Kim, S.J.; Shin, B.G.; Choi, I.Y.; Kim, D.H.; Kim, M.C.; Myung, N.Y.; Moon, P.D.; Lee, J.H.; An, H.J.; Kim, N.H.; Lee, J.Y.; So, H.S.; Park, R.K.; Jeong, H.J.; Um, J.Y.; Kim, H.M.; Hong, S.H.
Hwanggunchungyitang prevents cadmium-induced ototoxicity through suppression of the activation of caspase-9 and extracellular signal-related kinase in auditory HEI-OC1 cells (2009), Biol. Pharm. Bull., 32, 213-219.

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Application

Application	Comment	Organism
pharmacology	therapeutic usefulness of the herbal drug Hwanggunchungyitang (HGCYT) against cadmium (Cd2+)-induced activation of caspase-9	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	activation of caspase-9 by Cd2+ is inhibited by treatment with the herbal drug Hwanggunchungyitang (HGCYT) in a dose-dependent manner, pretreatement of cells with 0.01-1 mg/ml inhibitor for 1 h, treatment with 10 microM Cd2+ for 24 h	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cd2+	induces activation of caspase-9, decreases expression of the inactive form pro-caspase-9	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9R0T0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cochlea	cochlear cell line HEI-OC1	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	protective effect of the herbal drug Hwanggunchungyitang (HGCYT) against activation of caspase-9 by Cd2+, activity of caspase-9 measured by colorimetric assay and Western Blot analysis	Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	activity assay at	Mus musculus

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Release 2023.1 (January 2023)