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Literature summary for 3.4.22.61 extracted from

  • Ahmad, K.; Khan, S.; Adil, M.; Saeed, M.; Srivastava, A.K.
    Structure based molecular inhibition of Caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds (2014), Bioinformation, 10, 191-195.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-IETD-aldehyde
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
-
-

General Information

General Information Comment Organism
malfunction caspase-8 is coupled with the regulation of various neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease and dentatorubral pallidoluysian atrophy Homo sapiens
physiological function the enzyme is a key mediator of neuronal apoptosis Homo sapiens