Application | Comment | Organism |
---|---|---|
medicine | CASP8 is a candidate gene for multiple sclerosis risk. CASP8 polymorphisms are associated with increased risk for disease susceptibility in primary progressive multiple sclerosis patients and act as genetic modifiers of the progression of multiple sclerosis in patients with this clinical form | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Casp8 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | a significant downregulation in CASP8 expression is observed after cell activation in multiple sclerosis patients homozygotes for the protective (ACT/ACT) and risk haplotypes (GCA/GCA) | down |