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Literature summary for 3.4.22.59 extracted from

  • Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
    Inhibition of human caspases by peptide-based and macromolecular inhibitors (1998), J. Biol. Chem., 273, 32608-32613.
    View publication on PubMed
Search for more literature for 3.4.22.59

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetyl-AEVD-aldehyde
-
 Homo sapiens
acetyl-DEVD-aldehyde
-
 Homo sapiens
acetyl-IETD-aldehyde
-
 Homo sapiens
acetyl-WEHD-aldehyde
-
 Homo sapiens
benzyloxycarbonyl-VAD-fluoromethylketone t1/2 at 0.001 mM is 98 s Homo sapiens
additional information KI-value above 0.01 mM for acetyl-YVAD-aldehyde Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000056
-
 acetyl-IETD-aldehyde pH 7.5, 25°C Homo sapiens
0.000031
-
 acetyl-DEVD-aldehyde pH 7.5, 25°C Homo sapiens
0.000052
-
 acetyl-AEVD-aldehyde pH 7.5, 25°C Homo sapiens
0.0013
-
 cowpox serpin CrmA pH 7.5, 25°C Homo sapiens
0.003
-
 acetyl-WEHD-aldehyde pH 7.5, 25°C Homo sapiens