Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Nakatsumi, H.; Yonehara, S.
    Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells (2010), J. Biol. Chem., 285, 25418-25425.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.56

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged caspase-3 in DKD cells. Simultaneous expression of HA-procaspase-3 and HA-procaspase-7, EC 3.4.22.60, in DKD HeLa cells together with FLAG-caspase-3 or FLAG-caspase-7. HA-procaspase-3 is coimmunoprecipitated with FLAG-procaspase-3 but not with FLAG-procaspase-7. Similarly, HA-procaspase-7 is co-immunoprecipitated with FLAG-procaspase-7 but not with FLAG-procaspase-3 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information caspase-3 knockout by shRNA, generation of double knockdown cells lacking caspase-3 and caspase-7, EC 3.4.22.60, activity. Generation of caspase-7-based chimeric constructs with various regions of caspase-3, EC 3.4.22.56 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procaspase-6 + H2O Homo sapiens
-
 caspase-6 + ?
-
 ?
SETbeta + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42574
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-4-nitroanilide + H2O
-
 Homo sapiens DEVD + 4-nitroaniline
-
 ?
procaspase-6 + H2O
-
 Homo sapiens caspase-6 + ?
-
 ?
SETbeta + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
DEVDase
-
 Homo sapiens