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Literature summary for 3.4.22.56 extracted from

  • Park, M.J.; Kwon, H.Y.; Lee, E.O.; Lee, H.J.; Ahn, K.S.; Kim, M.O.; Kim, C.H.; Ahn, K.S.; Kim, S.H.
    DMNQ-S17 inhibits constitutive NF-kappaB activation leading to induction of apoptosis through the activation of caspase-3 in human myeloid leukemia U937 cells (2008), Life Sci., 83, 460-467.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information 6-(1-oxoallkyl)-5,8-dimethoxy-1,4-naphthoquinone-S17, i.e. DMNQ-S17, induces caspase-3 expression and activation via inhibition of NF-kappaB activation, and apoptosis, apoptotic mechanism, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-3 is involved in apoptosis in myeloid leukemia cells, Bcl-2 family proteins are the central regulators of caspases activation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-3 is activated from procaspase-3 by cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell myeloid leukemia cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-3 is involved in apoptosis in myeloid leukemia cells, Bcl-2 family proteins are the central regulators of caspases activation, overview Homo sapiens ?
-
 ?