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Literature summary for 3.4.22.56 extracted from

  • Caballero, B.; Vega-Naredo, I.; Sierra, V.; Huidobro-Fernandez, C.; Soria-Valles, C.; De Gonzalo-Calvo, D.; Tolivia, D.; Pallas, M.; Camins, A.; Rodriguez-Colunga, M.J.; Coto-Montes, A.
    Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice (2009), J. Pineal Res., 46, 106-114.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-3 is one of the key executioners of apoptosis and responsible for the partial or total proteolytic cleavage of many proteins. Senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, but the caspase-independent cell death, owing to high p53 and apoptosis-inducing factor levels, might be an alternative pathway of cell death in the aged brain ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, overview Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-spectrin + H2O
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 Mus musculus ? production of a 120 kDa fragment ?
additional information caspase-3 is one of the key executioners of apoptosis and responsible for the partial or total proteolytic cleavage of many proteins. Senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, but the caspase-independent cell death, owing to high p53 and apoptosis-inducing factor levels, might be an alternative pathway of cell death in the aged brain Mus musculus ?
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