Literature summary for 3.4.22.56 extracted from

Barry, G.M.; Breakwell, L.; Fragkoudis, R.; Attarzadeh-Yazdi, G.; Rodriguez-Andres, J.; Kohl, A.; Fazakerley, J.K.
PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type-I interferon response (2009), J. Gen. Virol., 90, 1382-1391.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	alphavirus Semliki Forest virus infection initiates apoptosis with increased caspase-3 activation, and interferon synthesis in embryonic fibroblasts, overview	Mus musculus

Application

Application	Comment	Organism
diagnostics	caspase-3 is a marker of apoptotic cell death in embryonic fibroblasts, NIH-3T3 and WST-1 cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	embryonic	Mus musculus	-
NIH-3T3 cell	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	caspase-3 activity in Semliki Forest virus-infected cells, overview	Mus musculus

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Release 2023.1 (January 2023)