Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cytochrome c | forebrain ischemia causes release of cytochrome c from mitochondria and translocation to the nucleus, which induces caspase-3 activation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bradykinin | prevents caspase-3 activation in neurons | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | increased cytosolic cytochrome c and subsequently caspase-3 activation are additional signs of neuronal death via the mitochondrial pathway. Bradykinin administration significantly attenuates ischemia-induced neuronal death, and also suppresses the release of MnSOD, and cytochrome c, and prevents caspase-3 activation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
forebrain | - |
Rattus norvegicus | - |
hippocampus | CA1 region | Rattus norvegicus | - |
neuron | pyramidal CA1 | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
caspase-3 activity in healthy hippocampus, hippocampus after 8 min of transient forebrain ischemia, and after 3 days of reperfusion, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Asp-Glu-Val-Asp-4-nitroanilide + H2O | - |
Rattus norvegicus | Asp-Glu-Val-Asp + 4-nitroaniline | - |
? | |
additional information | increased cytosolic cytochrome c and subsequently caspase-3 activation are additional signs of neuronal death via the mitochondrial pathway. Bradykinin administration significantly attenuates ischemia-induced neuronal death, and also suppresses the release of MnSOD, and cytochrome c, and prevents caspase-3 activation | Rattus norvegicus | ? | - |
? |