Literature summary for 3.4.22.56 extracted from

Pan, J.; Quintas-Cardama, A.; Manshouri, T.; Giles, F.J.; Lamb, P.; Tefferi, A.; Cortes, J.; Kantarjian, H.; Verstovsek, S.
The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1 (2007), Leukemia, 21, 1395-1404.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Mcl-1 + H2O	Homo sapiens	antiapoptotic protein. Caspase-3 -mediated Mcl-1 downregulation appears to be responsible for the pro-apoptotic effects of EXEL-0862 on FIP1L1-PDGFRalpha-expressing cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Mcl-1 + H2O	antiapoptotic protein. Caspase-3 -mediated Mcl-1 downregulation appears to be responsible for the pro-apoptotic effects of EXEL-0862 on FIP1L1-PDGFRalpha-expressing cells	Homo sapiens	?	-	?
Mcl-1 + H2O	antiapoptotic protein	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)