Literature summary for 3.4.22.56 extracted from

Faraglia, B.; Bonsignore, A.; Scaldaferri, F.; Boninsegna, A.; Cittadini, A.; Mancuso, C.; Sgambato, A.
Caspase-3 inhibits the growth of breast cancer cells independent of protease activity (2005), J. Cell. Physiol., 202, 478-482.

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Protein Variants

Protein Variants	Comment	Organism
C163G	transfection of human breast cancer cells lacking enzyme with wild-type or mutant cDNA. Expression of wild-type, but not the inactive mutants C163G or C163S, is associated with increased enzyme activity and susceptibility to staurosporine-induced apoptosis. Wild-type and mutant transfection results in inhibition of cell growth and decrease in phosphorylation of the Akt protein compared to control	Rattus norvegicus
C163S	transfection of human breast cancer cells lacking enzyme with wild-type or mutant cDNA. Expression of wild-type, but not the inactive mutants C163G or C163S, is associated with increased enzyme activity and susceptibility to staurosporine-induced apoptosis. Wild-type and mutant transfection results in inhibition of cell growth and decrease in phosphorylation of the Akt protein compared to control	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	expression in MCF-7 human breast cancer cell	-

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Release 2023.1 (January 2023)