Activating Compound | Comment | Organism | Structure |
---|---|---|---|
pancreatic derived factor | islet specific cytokine, capable of inducing apoptosis, increases levels of cleaved CASP3 in beta-TC3 cells | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | PANDER-induced downregulation of cyclin-dependent kinase inhibitor 1A expression coupled with induced CASP3-activation may serve a central role in islet cell death and offers further insight into the mechanisms of cytokine-induced beta-cell apoptosis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
C57B1/6 | - |
Mus musculus C57/BL6 | - |
C57B1/6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
beta-TC3 cell | insulinoma cell, treatment with islet-specific cytokine pancreatic derived factor results in elevated enzyme levels which abrogates expression of cyclin-dependent kinase inhibitor 1A | Mus musculus | - |
additional information | beta-TC3 murine inulinoma cells | Mus musculus | - |
pancreas | islet cell | Mus musculus | - |
pancreatic islet | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CASP3 | - |
Mus musculus |