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Literature summary for 3.4.22.56 extracted from

  • Zhang, Y.; Bhavnani, B.R.
    Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens (2006), BMC Neurosci., 7, 49.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine during glutamte-induced apoptotic cell death, at least two mechanisms are involved: a caspase-3-dependent pathway and an enzyme-independent pathway using calpain and apoptosis inducing factor Mus musculus
medicine during glutamte-induced apoptotic cell death, glutamate induces activation of calpain, enzyme and translocation of mitochondrial apoptosis inducing factor AIF to cytosol and nuclei. These processes are inhibited/reversed by 17beta-estradiol and DELTA8,17beta-estradiol with the latter being more potent Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
HT-22 cell hippocampal cell line, during glutamate-induced apoptotic cell death, glutamate induces activation of calpain, and translocation of mitochondrial apoptosis inducing factor AIF to cytosol and nuclei. Enzyme is not involved Mus musculus
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neuron neuronal cortical cell, during glutamte-induced apoptotic cell death, glutamate induces activation of calpain, enzyme and translocation of mitochondrial apoptosis inducing factor AIF to cytosol and nuclei. These processes are inhibited/reversed by 17beta-estradiol and DELTA8,17beta-estradiol with the latter being more potent Rattus norvegicus
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