Application | Comment | Organism |
---|---|---|
medicine | during glutamte-induced apoptotic cell death, at least two mechanisms are involved: a caspase-3-dependent pathway and an enzyme-independent pathway using calpain and apoptosis inducing factor | Mus musculus |
medicine | during glutamte-induced apoptotic cell death, glutamate induces activation of calpain, enzyme and translocation of mitochondrial apoptosis inducing factor AIF to cytosol and nuclei. These processes are inhibited/reversed by 17beta-estradiol and DELTA8,17beta-estradiol with the latter being more potent | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-22 cell | hippocampal cell line, during glutamate-induced apoptotic cell death, glutamate induces activation of calpain, and translocation of mitochondrial apoptosis inducing factor AIF to cytosol and nuclei. Enzyme is not involved | Mus musculus | - |
neuron | neuronal cortical cell, during glutamte-induced apoptotic cell death, glutamate induces activation of calpain, enzyme and translocation of mitochondrial apoptosis inducing factor AIF to cytosol and nuclei. These processes are inhibited/reversed by 17beta-estradiol and DELTA8,17beta-estradiol with the latter being more potent | Rattus norvegicus | - |