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Literature summary for 3.4.22.56 extracted from

  • Smith, L.; Chen, L.; Reyland, M.E.; DeVries, T.A.; Talanian, R.V.; Omura, S.; Smith, J.B.
    Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system (2000), J. Biol. Chem., 275, 40620-40627.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein kinase Czeta + H2O Homo sapiens major cleavage site EETD-/-G, also cleaves at DGMD-/-G and DSED-/-L. Caspase-3 is involved in processing of protein kinase Czeta to carboxyl-terminal fragments that are catalytically active and that are degraded by the ubiquitin-proteasome pathway ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 recombinant enzyme expressed in Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein kinase Czeta + H2O major cleavage site EETD-/-G, also cleaves at DGMD-/-G and DSED-/-L Homo sapiens ?
-
 ?
protein kinase Czeta + H2O major cleavage site EETD-/-G, also cleaves at DGMD-/-G and DSED-/-L. Caspase-3 is involved in processing of protein kinase Czeta to carboxyl-terminal fragments that are catalytically active and that are degraded by the ubiquitin-proteasome pathway Homo sapiens ?
-
 ?