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Literature summary for 3.4.22.56 extracted from

  • Schlegel, J.; Peters, I.; Orrenius, S.; Miller, D.K.; Thornberry, N.A.; Yamin, T.T.; Nicholson, D.W.
    CPP32/apopain is a key interleukin 1beta converting enzyme-like protease involved in Fas-mediated apoptosis (1996), J. Biol. Chem., 271, 1841-1844.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0139
-
 acetyl-DEVD-7-amido-4-methylcoumarin enzyme purified from THP.1 cells Homo sapiens
0.0144
-
 acetyl-DEVD-7-amido-4-methylcoumarin partially purified enzyme from Jurkat T cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
T-cell leukemia cell
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-DEVD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens acetyl-DEVD + 7-amino-4-methylcoumarin
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information Ki-value for enzyme from THP.1 cells with the inhibitor Ac-DEVD-aldehyde is below 1 nM Homo sapiens