Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Marissen, W.E.; Lloyd, R.E.
    Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells (1998), Mol. Cell. Biol., 18, 7565-7574.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eIF4G + H2O Homo sapiens caspase 3 is capable of cleaving eIF4G as part of the translationally active complex eIF4F, thereby inactivating this complex and subsequently causing inhibition of translation in apoptotic cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme expressed in Escherichia coli
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa-S3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eIF4G + H2O
-
Homo sapiens ?
-
?
eIF4G + H2O caspase 3 is capable of cleaving eIF4G as part of the translationally active complex eIF4F, thereby inactivating this complex and subsequently causing inhibition of translation in apoptotic cells Homo sapiens ?
-
?