Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Mch4 | activation of CPP32 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Asp-Glu-Val-Asp-aldehyde | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
full-length proCPP32 has a molecular weight of 32000-33000 Da | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42574 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | both Mch4 and granzyme B cleave recombinant proCPP32 at a conserved IXXD-S sequence to produce the large and small subunits of the active protease. Granzyme B cleaves at Asp175 to generate the small C-terminal subunit, 12000 Da, and te large N-terminal subunit. Cleavage of the prodomain is an autocatalytic activity of the activated CPP32 | Homo sapiens |