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BRENDA support

Literature summary for 3.4.22.55 extracted from

  • Callaway, D.A.; Riquelme, M.A.; Sharma, R.; Lopez-Cruzan, M.; Herman, B.A.; Jiang, J.X.
    Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress (2015), Bone, 76, 40-48.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus P29594
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived macrophage
-
Mus musculus
-
RAW-264.7 cell
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Mus musculus
-

Synonyms

Synonyms Comment Organism
CASP-2
-
Mus musculus

General Information

General Information Comment Organism
malfunction the loss of caspase-2 in mice results in an osteopenic phenotype associated with increased numbers of osteoclasts in vivo. Mitochondrial reactive oxygen species are significantly increased in caspase-deficient precursors after receptor activator of nuclear factor kappa-B ligand administration Mus musculus
physiological function caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress Mus musculus