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Literature summary for 3.4.22.55 extracted from

  • Inayat-Hussain, S.H.; Chan, K.M.; Rajab, N.F.; Din, L.B.; Chow, S.C.; Kizilors, A.; Farzaneh, F.; Williams, G.T.
    Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells (2010), Toxicol. Lett., 193, 108-114.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Asp-Val-Ala-Asp-fluoromethylketone
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
x * 33000, active subunit Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-2 processing occurs in goniothalamin-treated Jurkat cells, cleavage to its active subunit (33 kDa) occurs as early as 3 h Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT E-6.1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Val-Asp-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Val-Asp-Val-Ala-Asp + 7-amino-4-methylcoumarin
-
?
Val-Asp-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin + H2O
-
Homo sapiens Val-Asp-Val-Ala-Asp + 7-amino-4-trifluoromethylcoumarin
-
?

Subunits

Subunits Comment Organism
? x * 33000, active subunit Homo sapiens

Synonyms

Synonyms Comment Organism
caspase-2
-
Homo sapiens