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Literature summary for 3.4.22.55 extracted from

  • Manzl, C.; Krumschnabel, G.; Bock, F.; Sohm, B.; Labi, V.; Baumgartner, F.; Logette, E.; Tschopp, J.; Villunger, A.
    Caspase-2 activation in the absence of PIDDosome formation (2009), J. Cell Biol., 185, 291-303.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification PIDD (p53-induced protein with a death domain [DD]), together with the bipartite adapter protein RAIDD (receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a DD), is implicated in the activation of pro–caspase-2 in a high molecular weight complex called the PIDDosome during apoptosis induction after DNA damage. Processing of caspase-2 is readily detected in the absence of PIDDosome formation in primary lymphocytes Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
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Mus musculus
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thymocyte
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Mus musculus
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Synonyms

Synonyms Comment Organism
caspase-2
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Mus musculus