Literature summary for 3.4.22.55 extracted from

Andersen, J.L.; Johnson, C.E.; Freel, C.D.; Parrish, A.B.; Day, J.L.; Buchakjian, M.R.; Nutt, L.K.; Thompson, J.W.; Moseley, M.A.; Kornbluth, S.
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2 (2009), EMBO J., 28, 3216-3227.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Xenopus laevis
commercial preparation of cDNA, in vitro transcription/translation	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
S135A	phosphorylation site	Homo sapiens
S135A	phosphorylation site, suppressed equally compared with wild type protein during mitosis	Xenopus laevis
S135A/S308A	rapidly processed in mitosis compared with caspase-2 S308A mutant	Xenopus laevis
S308A	phosphorylation site, S308 phosphorylated in mitosis, abrogates mitotic suppression, processing of mutant S308A in mitosis does not occur immediately, but rather occurs with roughly the same kinetics as wild-type caspase-2 in interphase	Xenopus laevis
S340A	phosphorylation site, expression of mutant S340A more than doubles the sensitivity of cells to nocodazole-induced mitotic death compared with wild-type protein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Xenopus laevis	-	-	-

Synonyms

Synonyms	Comment	Organism
caspase-2	-	Homo sapiens
caspase-2	-	Xenopus laevis

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Release 2023.1 (January 2023)