Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-Val-Ala-Asp-fluoromethylketone | pan-caspase inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
coronary artery smooth muscle cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
caspase-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | The increased expression of PIDD (p53-induced protein with a death domain) induced by p53 forms a complex with RAIDD and caspase-2 (termed a PIDDosome), which activates the protease. The processed caspase-2 acts as a canonical caspase in the mitochondrial-mediated pathway triggering cytochrome c release. Once released to the cytoplasm, cytochrome c binds to APAF-1 to form a wheel-like complex, the apoptosome, resulting in the activation of caspase-9 and subsequent cleavage of downstream caspases including caspase-3. | Homo sapiens |