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Literature summary for 3.4.22.55 extracted from

  • Chan, K.M.; Rajab, N.F.; Siegel, D.; Din, L.B.; Ross, D.; Inayat-Hussain, S.H.
    Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway (2010), Toxicol. Sci., 116, 533-548.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Ala-Asp-fluoromethylketone pan-caspase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
coronary artery smooth muscle cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
caspase-2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function The increased expression of PIDD (p53-induced protein with a death domain) induced by p53 forms a complex with RAIDD and caspase-2 (termed a PIDDosome), which activates the protease. The processed caspase-2 acts as a canonical caspase in the mitochondrial-mediated pathway triggering cytochrome c release. Once released to the cytoplasm, cytochrome c binds to APAF-1 to form a wheel-like complex, the apoptosome, resulting in the activation of caspase-9 and subsequent cleavage of downstream caspases including caspase-3. Homo sapiens