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Literature summary for 3.4.22.54 extracted from

  • Dayanithi, G.; Richard, I.; Viero, C.; Mazuc, E.; Mallie, S.; Valmier, J.; Bourg, N.; Herasse, M.; Marty, I.; Lefranc, G.; Mangeat, P.; Baghdiguian, S.
    Alteration of sarcoplasmic reticulum ca release in skeletal muscle from calpain 3-deficient mice (2009), Int. J. Cell Biol., 2009, 340346.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.54

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ryanodine receptor + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myoblast
-
 Mus musculus
-
myotube
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ryanodine receptor + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain 3
-
 Mus musculus

General Information

General Information Comment Organism
malfunction deficiency in calpain 3 is associated with apoptosis as indicated by increases of caspase 3 activity, the absence of calpain 3 modifies the sarcoplasmic reticulum Ca2+ release, by a decrease of the sarcoplasmic reticulum content, an impairment of ryanodine receptor signalling, and an increase of L-type Ca2+ channel activity Mus musculus
physiological function calpain 3-dependent proteolysis plays a role in activating support proteins of intracellular Ca2+ signalling at a stage of cellular differentiation which is crucial for skeletal muscle regeneration Mus musculus