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Literature summary for 3.4.22.54 extracted from

  • Moretti, D.; Del Bello, B.; Cosci, E.; Biagioli, M.; Miracco, C.; Maellaro, E.
    Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions (2009), Carcinogenesis, 30, 960-967.
    View publication on PubMed
Search for more literature for 3.4.22.54

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleolus
-
 Homo sapiens 5730
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
84000
-
 full-length splice variant Mp84, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-144 cell
-
 Homo sapiens
-
Me665/2/21 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
SK-MEL cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
calpain 3
-
 Homo sapiens
MP78 splicing variant Homo sapiens
Mp84 splicing variant Homo sapiens
p94
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens among melanocytic lesions, the expression of the splicing variants of calpain 3 (Mp78 and Mp84) are significantly downregulated down

General Information

General Information Comment Organism
physiological function calpain 3 variants can play a proapoptotic role in melanoma cells and its downregulation, as observed in highly aggressive lesions, can contribute to melanoma progression Homo sapiens