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Literature summary for 3.4.22.54 extracted from

  • Mellgren, R.L.; Miyake, K.; Kramerova, I.; Spencer, M.J.; Bourg, N.; Bartoli, M.; Richard, I.; Greer, P.A.; McNeil, P.L.
    Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases (2009), Biochim. Biophys. Acta, 1793, 1886-1893.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
titin + H2O Mus musculus
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 ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
muscle calpain-3 is localized at the skeletal muscle M-line, Z-band, and the N2A region of the large myofibrillar protein, titin Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
titin + H2O
-
 Mus musculus ?
-
 ?

General Information

General Information Comment Organism
malfunction inactivating mutations of the CAPN3 gene, encoding the muscle-specific calpain-3, result in the limb-girdle muscular dystrophy-2A Mus musculus
physiological function calcium-dependent plasma membrane repair does not require calpain-3 Mus musculus