Literature summary for 3.4.22.54 extracted from

Benayoun, B.; Baghdiguian, S.; Lajmanovich, A.; Bartoli, M.; Daniele, N.; Gicquel, E.; Bourg, N.; Raynaud, F.; Pasquier, M.A.; Suel, L.; Lochmuller, H.; Lefranc, G.; Richard, I.
NF-{kappa}B-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A (2007), FASEB J., 22, 1521-1529.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle fibre	isolated from LGMD2A patients. CAPN3 intervenes in the regulation of the expression of NF-kappaB-dependent survival genes to prevent apoptosis in skeletal muscle. Deregulations in the NF-kappaB pathway could be part of the mechanism responsible for the muscle wasting resulting from CAPN3 deficiency	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
CAPN3	-	Homo sapiens

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Release 2023.1 (January 2023)