Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.52 extracted from

  • Nanduri, J.; Wang, N.; Yuan, G.; Khan, S.A.; Souvannakitti, D.; Peng, Y.J.; Kumar, G.K.; Garcia, J.A.; Prabhakar, N.R.
    Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities (2009), Proc. Natl. Acad. Sci. USA, 106, 1199-1204.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(acetoxymethyl) ester
-
Rattus norvegicus
acetyl-Leu-Leu-Met-CHO
-
Rattus norvegicus
acetyl-Leu-Leu-Nle-CHO
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
calpain 1
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus calpain activity increases in cells exposed to intermittent hypoxia 60 and 0.01 mM 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(acetoxymethyl) ester prevents this effect down
Rattus norvegicus ionomycin and thapsigragin, which elevate [Ca2+], activate calpains in cells exposed to normoxia up

General Information

General Information Comment Organism
physiological function calpain 1 activation contributes to HIF-2alpha degradation by IH Rattus norvegicus