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Literature summary for 3.4.22.52 extracted from

  • Vosler, P.S.; Sun, D.; Wang, S.; Gao, Y.; Kintner, D.B.; Signore, A.P.; Cao, G.; Chen, J.
    Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways (2009), Exp. Neurol., 218, 213-220.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.52

Inhibitors

Inhibitors Comment Organism Structure
calpastatin
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calpain I is a calcium-dependent protease Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apoptosis-inducing factor + H2O calpain-mediated truncation of apoptosis-inducing factor is contingent upon poly(ADP-ribose) polymerase-1 activity Rattus norvegicus ?
-
 ?
E-(EDANS)-PLFAERK-(Dabcyl) + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain I
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction calpain inhibition prevents NMDA-induced AIF truncation and nuclear translocation in neurons Rattus norvegicus