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Literature summary for 3.4.22.52 extracted from

  • Kelly, J.C.; Cuerrier, D.; Graham, L.A.; Campbell, R.L.; Davies, P.L.
    Profiling of calpain activity with a series of FRET-based substrates (2009), Biochim. Biophys. Acta, 1794, 1505-1509.
    View publication on PubMed
Search for more literature for 3.4.22.52

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
integrin + H2O Homo sapiens
-
 ?
-
 ?
MAP2 + H2O Homo sapiens
-
 ?
-
 ?
spectrin + H2O Homo sapiens
-
 ?
-
 ?
talin + H2O Homo sapiens
-
 ?
-
 ?
tau protein + H2O Homo sapiens
-
 ?
-
 ?
vimentin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(EDANS)-EALFAERK-(DABCYL) + H2O about 30% cleavage preference Homo sapiens (EDANS)-EA + LFAERK-(DABCYL)
-
 ?
(EDANS)-EPLFAARK-(DABCYL) + H2O the sequence PLFAAR is an even better substrate for the calpain 1 protease core than PLFAER, 100% cleavage preference Homo sapiens (EDANS)-EPLFA + ARK-(DABCYL)
-
 ?
(EDANS)-EPLFAERK-(DABCYL) + H2O about 40% cleavage preference Homo sapiens (EDANS)-EPLFA + ERK-(DABCYL)
-
 ?
(EDANS)-EPLFGERK-(DABCYL) + H2O less than 20% cleavage preference Homo sapiens (EDANS)-EPLF + GERK-(DABCYL)
-
 ?
(EDANS)-EPLFMERK-(DABCYL) + H2O the peptide sequence PLFMER is rapidly cleaved by the calpain 1 core at the F-M bond with about 45% cleavage preference Homo sapiens (EDANS)-EPLF + MERK-(DABCYL)
-
 ?
integrin + H2O
-
 Homo sapiens ?
-
 ?
MAP2 + H2O
-
 Homo sapiens ?
-
 ?
additional information (EDANS)-EPAFAERK-(DABCYL), (EDANS)-EPLAAERK-(DABCYL), and (EDANS)-EPLFAEAK-(DABCYL) are very weak substrates for calpain 1 core Homo sapiens ?
-
 ?
spectrin + H2O
-
 Homo sapiens ?
-
 ?
talin + H2O
-
 Homo sapiens ?
-
 ?
tau protein + H2O
-
 Homo sapiens ?
-
 ?
vimentin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain 1
-
 Homo sapiens
mu-calpain
-
 Homo sapiens
muI-II calpain 1 protease core Homo sapiens